Hypoxia-NRF2 Activation
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
This module combines hypoxia/oxidative-stress effectors (VEGFA, NFE2L2/NRF2) with an inflammatory receptor (IL1R1), the collagen-specific chaperone SERPINH1/HSP47, and cytoskeletal remodeling/plasticity genes (LIMA1, MYADM, ZEB2) - the signature of a stress-activated, partially de-differentiated mural/myofibroblast state rather than a resting one. REV3L and UPF3A are peripheral housekeeping members diluting coherence. Neighborhood context supports this: M0 captures the quiescent pericyte/mural identity and M95 the secretory machinery, so M21 is the activation/stress-response axis of the same cells (SERPINH1 links directly to the collagen-secretion program of M95).
Genes
IL1R1, LIMA1, MYADM, NFE2L2, REV3L, SERPINH1, UPF3A, VEGFA, ZEB2
Most correlated modules
- ER Chaperone/UPR · correlation 0.73
- XBP1 UPR Response · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.