ER Chaperone/UPR
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Dominated by the classical ER folding/chaperone machinery (PDIA3, CALR, HSP90B1, HSPA5/BiP, PPIB), i.e. a UPR/secretory-capacity program, with collagen-processing partners (PPIB, PCOLCE, CRISPLD2). The cytokine receptors OSMR/IL6ST and HIF1A are the upstream drivers that up-regulate this secretory program in activated stromal cells, explaining why this module neighbors the inflammatory M69/M117 and the pure ER modules M64/M121.
Genes
CALR, CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, OSMR, PCOLCE, PDIA3, PPIB, RHOBTB3
Most correlated modules
- ER Secretory Trafficking · correlation 0.86
- Activated Myofibroblast · correlation 0.84
- Matrix-integrin interaction · correlation 0.78
- Hypoxia-NRF2 Activation · correlation 0.73
- Mesenchymal Adhesion Program · correlation 0.72
- ER-Golgi Secretory Pathway · correlation 0.70
- Redox-Metabolic Housekeeping · correlation 0.70
- IFN-gamma/NF-kB Response · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.