XBP1 UPR Response
Gene co-expression module in Smooth muscle cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
XBP1 is the dominant hub with HERPUD1, the canonical IRE1-XBP1 UPR target; TMEM165 (Golgi Ca/Mn homeostasis), ATP1A1 and BNIP3L add secretory/organelle stress components, while NFKBIA, SOCS1 and BATF3 represent the NF-kB/stress-coupled arm frequently co-induced with UPR. Neighbors M22 (ER-Golgi trafficking, ATP2A2) reinforce an ER-secretory axis; the presence of immediate NF-kB feedback genes without a full dissociation signature argues for genuine UPR/stress signalling rather than pure artifact.
Genes
ADAMTS10, AKAP13, ATP1A1, BATF3, BNIP3L, CHRD, DLC1, HERPUD1, MICAL1, NFKBIA, SOCS1, TMEM165, XBP1, YWHAB
Most correlated modules
- NF-kB Stress Response · correlation 0.76
- BMP-ID3 Matricellular · correlation 0.67
- Stromal Chemokine Secretion · correlation 0.62
- IFN-gamma/NF-kB Response · correlation 0.61
- NR4A-ADAMTS Activation · correlation 0.58
- ER-Golgi Secretory · correlation 0.52
- Hypoxia-NRF2 Activation · correlation 0.50
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.