ZEB2 — Zinc finger E-box binding homeobox 2

ZEB2 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ZEB2's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Atypical memory B cell B cell maturation	FCRL5, FGR, HCK, HEXA, HMOX1, ITGAX, LRRK2, MED13L +5 more	View in SCUBA
CD4⁺ T cells	TCR Complex Activation TCR/AP1/NFKb pathway	ABHD17A, ACTR3, C1GALT1, CD2, CD3D, CD3E, CD3G, CD81 +14 more	View in SCUBA
CD8⁺ T cells	CD8 Effector Maturation T cell maturation	AKAP13, ATXN1, CD81, DDX17, DDX3X, ETS1, IKZF3, JUND +8 more	View in SCUBA
Gamma-delta T cells	NK-like Terminal Differentiation T cell maturation	EPB41L4A, FCRL6, JAZF1, LILRB1, MLC1, PRR5L, SYT11
Glial cells	Peripheral Glial Myelination Myelination	FAM210B, FRMD6, GNAS, KDSR, MAF, MYL9, OLFML2A, OLFML3 +7 more	View in SCUBA
Hematopoietic progenitor cells	HSC Progenitor Proliferation Stemness	AMD1, CDK6, GNAQ, GSE1, MYB, RNF24, SPN, STAT5A
Macrophages	Chromatin Regulatory Genes Housekeeping	ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN +31 more	View in SCUBA
Natural Killer cells	NK Cell Maturation Differentiation	CAST, GNG2, GZMB, HIPK2, PPP2R5C, PRKCH, STK10, SYNE2	View in SCUBA
Pericytes	Pericyte Identity Differentiation Developmental	ADAMTS5, ARHGAP15, EPB41L2, GUCY1A1, INPP4B, LGI4, LMOD1, MAP1LC3A +11 more	View in SCUBA
Smooth muscle cells	Hypoxia-NRF2 Activation Stress	IL1R1, LIMA1, MYADM, NFE2L2, REV3L, SERPINH1, UPF3A, VEGFA	View in SCUBA

About the gene

Synonyms	KIAA0569, SIP-1, SIP1, ZFHX1B
Chromosome	2: 144364364-144521057
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.