SERPINH1 — Serpin family H member 1
SERPINH1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Heat Shock Response Stress | DNAJA4, DNAJB1, DNAJB4, HSPA1A, HSPA1B, HSPA6, HSPB1, PLIN2 +3 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Stress | CRK, DLC1, GCLM, IFT20, KRAS, ODC1, SBDS, SERP1 +7 more | View in SCUBA |
| Gamma-delta T cells | ER/Osmotic Stress Stress | ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2 +7 more | |
| Macrophages | Early response genes Inflammatory | ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more | View in SCUBA |
| Monocytes | Co-chaperone Proteostasis Stress | AHSA1, ALAS1, BAG3, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1 +2 more | View in SCUBA |
| Natural Killer cells | Inducible HSP70 Stress Stress | BAG3, DNAJB1, FKBP4, HSPA1A, HSPA1B, HSPA4, HSPA6, HSPB1 +2 more | View in SCUBA |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, ASAP1, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, TCEAL9 +2 more | View in SCUBA |
| Smooth muscle cells | Hypoxia-NRF2 Activation Stress | IL1R1, LIMA1, MYADM, NFE2L2, REV3L, UPF3A, VEGFA, ZEB2 | View in SCUBA |
About the gene
| Synonyms | CBP1, CBP2, HSP47, SERPINH2 |
|---|---|
| Chromosome | 11: 75562056-75572783 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Stress response |
Function
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.