REV3L — REV3 like, DNA directed polymerase zeta catalytic subunit

REV3L belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

REV3L's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	DNA repair/replication DNA/chromatin regulation	ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, HELB +4 more	View in SCUBA
Endothelial	Venous EC Identity Endothelial cell development	ACTN1, AK4, CCL14, CTTNBP2, DAPK1, EPB41L3, FAM171A1, IL1R1 +18 more	View in SCUBA
Gamma-delta T cells	Centrosome Organization DNA/chromatin regulation	AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A +23 more
Innate lymphoid cells	Endosomal Trafficking Protein processing & ER	ARL14EP, CCDC90B, CLINT1, ESF1, MDFIC, MDM4, MPHOSPH8, NRIP1 +11 more	View in SCUBA
Lymphatic endothelial	Chromatin Remodeling DNA/chromatin regulation	BAZ2B, CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB +4 more	View in SCUBA
Smooth muscle cells	Hypoxia-NRF2 Activation Stress	IL1R1, LIMA1, MYADM, NFE2L2, SERPINH1, UPF3A, VEGFA, ZEB2	View in SCUBA

About the gene

Synonyms	POLZ, REV3
Chromosome	6: 111299028-111483715
Predicted location	Intracellular
Essential gene	Yes
Protein class	Enzymes, Essential proteins, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological process	DNA damage, DNA repair, DNA replication

Function

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.