RNA Splicing Regulation
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 36 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by RNA-binding and splicing factors: HNRNPU, HNRNPA2B1 (hnRNP family), TRA2A, TRA2B (SR-related splicing regulators), FUS (RNA processing), RNPS1 (splicing activator), RBM39 (splicing factor), PNN (splicing/transcription coactivator), ARGLU1 (splicing regulator), TAF15 (transcription/RNA processing). RBBP4, RBBP6 (chromatin/histone chaperones), ATRX (chromatin remodeling), BDP1 (RNA Pol III transcription factor) add chromatin/transcription context. NOP56 (rRNA processing, crypt-enriched) links to neighbor M37. This is a tight RNA splicing and processing module.
Genes
Most correlated modules
- Vesicular Trafficking · correlation 0.85
- Ribosome Biogenesis · correlation 0.83
- Mitochondrial Ribosome · correlation 0.82
- Mitochondrial Maintenance · correlation 0.79
- BEST4 Colonocyte Identity · correlation 0.78
- Stem Cell Epigenetic · correlation 0.74
- Metabolic Homeostasis · correlation 0.71
- Dissociation Stress Artifact · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.