BEST4 Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
MEIS1 (75x BEST4 enrichment), PROX1 (46x BEST4), NBPF14 (16x BEST4), PBX1 (2.8x BEST4), SHTN1 (2.6x BEST4), ATG16L2 (5.4x BEST4), NSD2 (2.5x BEST4) are all strongly enriched in BEST4+ colonocytes. MEIS1 and PROX1 are transcription factors known to define BEST4+OTOP2+ colonocyte identity. This module represents the transcriptional identity program of BEST4 colonocytes. The few uniform genes (ASAH1, VPS35, PPP3CA) are likely co-regulated housekeeping genes in this cell type.
Genes
Most correlated modules
- Vesicular Trafficking · correlation 0.83
- Ribosome Biogenesis · correlation 0.80
- RNA Splicing Regulation · correlation 0.78
- Stem Cell Epigenetic · correlation 0.75
- Mitochondrial Maintenance · correlation 0.74
- Ubiquitin-Proteasome System · correlation 0.72
- BEST4+ Colonocyte Identity · correlation 0.63
- Cellular Senescence · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.