ER-Golgi Trafficking
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub gene CLINT1 (clathrin interactor 1, endosomal trafficking), LRRC8B (volume-regulated anion channel subunit), PDZD8 (ER-mitochondria tethering, lipid transfer), FNDC3A (fibronectin domain-containing, ER/Golgi), NFIB (transcription factor), SLC7A1 (cationic amino acid transporter), NBN (Nibrin, DNA damage response), CANX (calnexin, ER chaperone), MAN1A2 (Golgi mannosidase, N-glycan processing), STT3A (oligosaccharyltransferase catalytic subunit). The module is significantly upregulated with inflammation (delta_inflammation sig.), particularly UC. The mix of ER/Golgi glycosylation (CANX, MAN1A2, STT3A), endosomal trafficking (CLINT1), DNA damage (NBN), and transcription (NFIB) suggests a mixed but coherent stress/inflammation-associated ER and trafficking program. The inflammation association and SLC7A1 enrichment in inf_colono support an inflammation-responsive ER/trafficking state. Neighbor M59 is a pure ER processing module; M118 shares ER components but adds trafficking and stress elements, consistent with an inflammation-induced ER stress/trafficking response.
Genes
Most correlated modules
- Mucin Glycosylation Biosynthesis · correlation 0.90
- Protein Homeostasis Housekeeping · correlation 0.89
- RNA-binding & Splicing · correlation 0.89
- Actin Cytoskeletal Regulation · correlation 0.87
- ER Protein Processing · correlation 0.86
- Unfolded Protein Response · correlation 0.86
- Chromatin-Coupled Splicing · correlation 0.84
- Mitochondrial Peroxisomal Metabolism · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.