Protein Homeostasis Housekeeping
Gene co-expression module in Colonocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include GSPT1 (translation termination factor), DDX1 (RNA helicase), LRRC59 (ribosome receptor on ER), SEC62 (ER translocation), MRPL13 (mitochondrial ribosomal protein), TCEA1 (transcription elongation), USP14 (proteasome-associated deubiquitinase), PSMD14 (proteasome subunit), RBM3 (RNA-binding protein, cold-shock), SNX2 (sorting nexin). The module is uniformly expressed, core coherence, and represents a broad housekeeping program involving mRNA metabolism, ER translocation, and protein homeostasis. The disease response shows significant decrease in CD inflammation and increase with CD treatment, consistent with a housekeeping program suppressed during active CD inflammation and restored with treatment. No single dominant pathway, but the combination of translation, ER targeting, and proteasome genes fits a general housekeeping/protein homeostasis signature. Neighbor context: M59 is clearly an ER/proteasome module; M138 shares ER (SEC62, LRRC59) and proteasome (USP14, PSMD14) genes, suggesting these are complementary housekeeping programs.
Genes
Most correlated modules
- CCT Chaperonin Folding · correlation 0.97
- RNA Processing Translation · correlation 0.96
- RNA-binding & Splicing · correlation 0.96
- Cell Cycle Machinery · correlation 0.95
- Mitochondrial Ribosome · correlation 0.94
- ER Protein Processing · correlation 0.93
- Proteasome Activity · correlation 0.92
- Mitochondrial Peroxisomal Metabolism · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.