RNA-binding & Splicing
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes: KHDRBS1 (Sam68, RNA-binding, splicing regulator), YY1 (transcription factor), CSDE1 (RNA-binding, translational regulation), HNRNPK (heterogeneous nuclear ribonucleoprotein K, RNA processing), KPNB1 (importin beta, nuclear transport), PCBP2 (RNA-binding), CAPRIN1 (stress granule, mRNA regulation), CELF1 (RNA-binding, splicing), PAPOLA (poly(A) polymerase), HNRNPF (RNA processing), PUM1 (post-transcriptional repressor), SRP9 (signal recognition particle), TNPO1 (transportin, nuclear import), ZMAT2 (splicing factor). This is a coherent module of RNA-binding proteins, splicing regulators, and nuclear transport factors — a post-transcriptional RNA processing program. Uniform expression across subsets. Neighbor M138 also has RNA metabolism genes (DDX1, RBM3), supporting a shared RNA processing neighborhood.
Genes
Most correlated modules
- Protein Homeostasis Housekeeping · correlation 0.96
- Actin Cytoskeletal Regulation · correlation 0.91
- CCT Chaperonin Folding · correlation 0.90
- ER Protein Processing · correlation 0.89
- ER-Golgi Trafficking · correlation 0.89
- Mitochondrial Peroxisomal Metabolism · correlation 0.89
- RNA Processing Translation · correlation 0.88
- Proteasome Activity · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.