Unfolded Protein Response
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 16 of 46 genes have a known function matching the annotation |
Why this annotation
Hub genes HSP90B1 (GRP94), HSPA5 (BiP/GRP78), PDIA3, PDIA4 (protein disulfide isomerases), CALR (calreticulin), MANF (ER stress factor), UFM1 (UFMylation/ER stress), SAR1A, COPA, ERGIC1 (COPII/ER-Golgi trafficking), and GALNT3 (O-glycosylation) collectively define a canonical ER protein quality control and unfolded protein response program. Enrichment in inf_colono is consistent with increased secretory demand during inflammation. Strong coherence supports a tight single program. Neighbor modules M15 and M70 share complementary ER/secretory programs, confirming this neighborhood is centered on ER/secretory biology.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.91
- ER Glycoprotein Folding · correlation 0.89
- Actin Cytoskeletal Regulation · correlation 0.88
- Secretory Differentiation · correlation 0.87
- Chromatin Regulatory Response · correlation 0.87
- ER-Golgi Trafficking · correlation 0.86
- ER Protein Processing · correlation 0.86
- RNA-binding & Splicing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.