ER Protein Processing
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 27 genes have a known function matching the annotation |
Why this annotation
Top hub genes are PDIA6 (protein disulfide isomerase), SPCS2 (signal peptidase complex), SSR2/SSR3 (signal sequence receptor/translocon), PPIB (cyclophilin B, ER folding), PRDX4 (ER-localized peroxiredoxin), OSTC/DDOST (oligosaccharyltransferase complex), KDELR1 (ER retention receptor), TMED2 (COPI vesicle), REEP5 (ER shaping), and multiple proteasome subunits (PSMA1, PSMA3, PSMA5, PSMB2). This is a tightly coherent module representing ER protein processing, N-glycosylation, and proteasomal degradation — classic ER quality control and secretory pathway. MYDGF is an ER-resident growth factor. Neighbor M138 shares proteasome and ER translocation genes, confirming these are related housekeeping/protein processing programs. The slight enrichment in crypt colonocytes for PRDX4 and inf_colono for PPA1 is minor.
Genes
Most correlated modules
- Proteasome Activity · correlation 0.96
- Protein Homeostasis Housekeeping · correlation 0.93
- RNA Processing Translation · correlation 0.92
- Proteasome Assembly · correlation 0.91
- Cell Cycle Machinery · correlation 0.91
- Mucin Glycosylation Biosynthesis · correlation 0.90
- Mitochondrial Ribosome · correlation 0.90
- RNA-binding & Splicing · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.