Colonocyte Senescence
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 16 genes have a known function matching the annotation |
Why this annotation
Nearly all genes are strongly enriched in sen_colono (2–3.9x). FBXO32 (atrogin-1) drives ubiquitin-mediated protein degradation associated with cellular atrophy and senescence. PRDM1 (BLIMP1) marks terminal differentiation/senescence. CLDN23 and TJP1 reflect tight junction remodeling in shedding colonocytes. DUSP5 and RCAN1 are stress-responsive phosphatase/calcineurin regulators. ARRDC4 is an arrestin-domain protein induced under stress. TICAM1 (TRIF) suggests innate immune activation in senescent cells. TMCC3 and MAPRE3 are highly enriched in sen_colono. The module is coherent (core) and tightly associated with the senescent colonocyte state. Neighbor M98 captures lysosomal/mTOR signaling that may regulate the transition into senescence.
Genes
Most correlated modules
- Senescent Stress Signaling · correlation 0.88
- Senescent Colonocyte Differentiation · correlation 0.88
- TNF Apoptosis Resistance · correlation 0.86
- mTOR Lysosomal Sensing · correlation 0.85
- AP-1 Stress Survival · correlation 0.85
- Senescent Colonocyte Identity · correlation 0.84
- Junction Cytoskeletal Remodeling · correlation 0.83
- ESCRT Membrane Remodeling · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.