ESCRT Membrane Remodeling
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 19 genes have a known function matching the annotation |
Why this annotation
CHMP4B and CHMP1A are ESCRT-III components involved in membrane scission, multivesicular body formation, and cytokinetic abscission — processes active in senescent cells releasing vesicles. PDCD6IP (ALIX) is an ESCRT accessory protein also involved in apoptosis. SIRT6 (sirtuin-6) is a chromatin deacetylase linked to senescence suppression and DNA repair. PRKCD (PKC-delta) promotes apoptosis in epithelial cells. TJP3/CGN encode tight junction proteins whose remodeling occurs during shedding. FBLIM1 (filamin-binding LIM protein) and MICAL2 are cytoskeletal regulators. ABHD12 (lipid hydrolase) and MGLL (monoglyceride lipase) suggest lipid remodeling. The ESCRT machinery combined with sen_colono enrichment and junction remodeling points to membrane/vesicle remodeling in senescent colonocytes.
Genes
Most correlated modules
- Colonocyte Cytoskeletal Contractility · correlation 0.96
- Senescent Stress Signaling · correlation 0.94
- Senescent Colonocyte Identity · correlation 0.93
- Mature Colonocyte Identity · correlation 0.92
- Senescent Cell Death · correlation 0.89
- Senescent Surface Identity · correlation 0.89
- Brush Border Cytoskeleton · correlation 0.88
- Junction Cytoskeletal Remodeling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.