AP-1 Stress Survival
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
FOSL2 and JUND are AP-1 transcription factor subunits activated by inflammatory and stress signals. SQSTM1 (p62) is a hub of NF-κB/autophagy signaling and stress response. MCL1 is an anti-apoptotic BCL-2 family member upregulated in survival responses. AKAP13 is a RhoA GEF and PKA scaffold linking inflammatory signaling to cytoskeletal remodeling. RND3 is a Rho GTPase that modulates actin dynamics. EZR (ezrin) links membrane to cytoskeleton. CLDN4 reflects tight junction remodeling. GLS (glutaminase) supports metabolic reprogramming under stress. The module is upregulated in inflammation across both UC and CD. Neighbor M25 captures the EGFR/wound-response arm; M124 represents the AP-1/NF-κB survival and stress arm of the same inflammatory colonocyte state.
Genes
Most correlated modules
- Colonocyte Senescence · correlation 0.85
- Senescent Colonocyte Transcription · correlation 0.82
- EGFR Wound Response · correlation 0.80
- Colonocyte Senescence · correlation 0.76
- Inflammatory Cytoskeletal Remodeling · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.