Senescent Colonocyte Differentiation
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 24 genes have a known function matching the annotation |
Why this annotation
CLCA4 (chloride channel accessory, highly expressed in differentiated colonocytes, 13.1x in sen_colono), EMP1 (epithelial membrane protein 1, 7.8x sen_colono), IL32 (pro-inflammatory cytokine, 6.5x sen_colono), SLCO2A1 (prostaglandin transporter, 5.9x sen_colono), MYO15B (myosin XVb, brush border, 5.6x), ABCG1 (cholesterol/lipid transporter, 5.0x), TRANK1 (4.2x), DDX60 (antiviral RNA helicase, 3.8x), IFNGR2 (IFN-γ receptor, 2.3x), ERBIN (ErbB2-interacting protein, 3.1x), PLOD2 (lysyl hydroxylase, collagen modification), GDA (guanine deaminase). The extreme sen_colono enrichment of CLCA4, EMP1, and MYO15B combined with interferon-response genes (DDX60, IFNGR2, IL32) and lipid/prostaglandin transporters suggests a senescent colonocyte differentiation state with innate immune activation. This is the most strongly sen_colono-specific module in the batch.
Genes
Most correlated modules
- Senescent Colonocyte Identity · correlation 0.94
- Senescent Stress Signaling · correlation 0.93
- TNF Apoptosis Resistance · correlation 0.91
- Senescent Cell Death · correlation 0.91
- Type I Interferon Response · correlation 0.90
- Junction Cytoskeletal Remodeling · correlation 0.89
- Senescent Surface Identity · correlation 0.89
- Colonocyte Senescence · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.