Senescent Stress Signaling
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes GNA13, PIP5K1B, GNG12 indicate G-protein/phosphoinositide signaling remodeling. PINK1 (mitophagy), CASP7 (executioner caspase), RNF144A (ubiquitin E3 ligase), CAB39 (AMPK scaffold), DYRK2 (stress-activated kinase), and NT5C2 collectively point to a stress-activated survival/death signaling program. Strong enrichment in sen_colono and significant upregulation in UC inflammation with reversal in remission supports a senescent colonocyte stress-signaling identity. MAPK6 (ERK3) and ATP1B3 further support kinase-driven stress adaptation.
Genes
Most correlated modules
- ESCRT Membrane Remodeling · correlation 0.94
- Senescent Colonocyte Identity · correlation 0.94
- Epithelial Junction Integrity · correlation 0.93
- Senescent Surface Identity · correlation 0.93
- Junction Cytoskeletal Remodeling · correlation 0.93
- Senescent Colonocyte Differentiation · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.92
- Senescent Cell Death · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.