Senescent Colonocyte Identity
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 19 genes have a known function matching the annotation |
Why this annotation
All 19 genes are consistently and strongly enriched in sen_colono (senescent colonocytes, 2.2–6.3x). Hub genes include MXI1 (MYC antagonist driving growth arrest/senescence), HPGD (prostaglandin catabolism, terminal colonocyte differentiation marker, tumor suppressor), BTNL3/BTNL8 (butyrophilin-like proteins characteristic of mature surface colonocytes), CTDSP2 (phosphatase promoting cell cycle exit), and SLC1A1 (colonocyte nutrient transporter). The module is core coherent with all genes showing core membership, indicating a tight, well-defined biological program. Together these genes define the transcriptional identity of terminally differentiated/senescent surface colonocytes undergoing growth arrest with preserved absorptive and immune-modulatory functions. The modest increase post-treatment is consistent with restoration of normal colonocyte differentiation.
Genes
Most correlated modules
- Senescent Stress Signaling · correlation 0.94
- Senescent Colonocyte Differentiation · correlation 0.94
- ESCRT Membrane Remodeling · correlation 0.93
- Brush Border Cytoskeleton · correlation 0.92
- Colonocyte Water Transport · correlation 0.91
- Mature Colonocyte Identity · correlation 0.89
- Senescent Surface Identity · correlation 0.86
- Senescent Cell Death · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.