Junction Cytoskeletal Remodeling
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include PPP2CB (PP2A catalytic subunit, regulates cytoskeletal phosphorylation), LASP1 (LIM/actin-binding), EPS8 (actin barbed-end capping), CTNNA1 (alpha-catenin, adherens junction), DSC2 (desmocollin-2, desmosome), CAPN2 (calpain-2, cytoskeletal protease), WDR1 (AIP1, actin disassembly), VILL (villin-like), DST (dystonin, cytoskeletal linker), SDCBP2 (syndecan-binding). The module captures cytoskeletal remodeling and junction disassembly consistent with senescent colonocyte morphological changes. TNFSF10 (TRAIL) adds an apoptosis/SASP component. Enriched in sen_colono and upregulated in UC inflammation.
Genes
Most correlated modules
- Senescent Surface Identity · correlation 0.93
- Senescent Stress Signaling · correlation 0.93
- TNF Apoptosis Resistance · correlation 0.92
- Epithelial Junction Integrity · correlation 0.91
- Senescent Cell Death · correlation 0.90
- Senescent Colonocyte Differentiation · correlation 0.89
- Endosomal Vesicle Trafficking · correlation 0.88
- ESCRT Membrane Remodeling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.