mTOR Lysosomal Sensing
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes RHEB, RRAGC, and LAMTOR3 define the Ragulator-mTORC1 nutrient sensing axis on lysosomes. RAB9A, VPS4B, and AP3S1 reflect late endosomal/lysosomal vesicle trafficking. UGCG, CERS2, and ADIPOR2 indicate sphingolipid/ceramide metabolism. F2RL1 (PAR2) links to inflammatory signaling. TNFRSF21 and UGCG show mild sen_colono enrichment. The module is significantly upregulated in UC inflammation, consistent with mTOR/lysosomal stress activation in inflamed colonocytes. Neighbor M139 captures the senescent colonocyte state, while M98 captures the upstream nutrient/lipid sensing machinery.
Genes
Most correlated modules
- Lysosomal Autophagy Trafficking · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.92
- Arp2/3 Actin Branching · correlation 0.91
- Integrin Adhesion Signaling · correlation 0.90
- Epithelial Junction Integrity · correlation 0.90
- EGFR Wound Response · correlation 0.89
- Colonocyte Senescence · correlation 0.85
- TNF Apoptosis Resistance · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.