Colonocyte Differentiation
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 19 genes have a known function matching the annotation |
Why this annotation
SATB2 is a top hub gene and a well-established master transcription factor for colonocyte identity and posterior gut specification. SLC9A2 (NHE2, apical Na+/H+ exchanger expressed in colonocytes), NIPAL1 (NIPA-like magnesium transporter), TRPM7 (Mg2+/Ca2+ channel) represent ion transport functions characteristic of mature colonocytes. LIN7C (epithelial polarity scaffold), ADD3 (adducin, membrane-cytoskeleton linker), GIPC2 (PDZ scaffold) support epithelial architecture. HOXA10 (homeobox TF, posterior gut patterning) reinforces colonocyte identity. HOOK1 (endosomal trafficking), ACADSB (branched-chain fatty acid oxidation), AGPAT5 (phospholipid synthesis) add metabolic/trafficking functions. Significantly downregulated in inflammation. This module represents mature colonocyte differentiation identity driven by SATB2.
Genes
Most correlated modules
- Mitochondrial Membrane Dynamics · correlation 0.91
- Mitochondrial Biogenesis · correlation 0.89
- Mitochondrial Peroxisomal Metabolism · correlation 0.89
- Colonocyte HOX Identity · correlation 0.86
- BMP-ID Progenitor · correlation 0.84
- Crypt Colonocyte Identity · correlation 0.84
- Spliceosome Assembly · correlation 0.81
- Oxidative Phosphorylation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.