ER Stress & Trafficking
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 36 genes have a known function matching the annotation |
Why this annotation
This module is significantly upregulated in UC inflammation (delta_inflammation_UC = 0.918, sig.). Hub genes include RAB14, RAB1A (endosomal/ER-Golgi vesicular trafficking), RAP1B (small GTPase, vesicle fusion), VAPA (ER-membrane contact sites), ERP44 (ER oxidoreductase, UPR), SARAF and ATP2A2/SERCA2 (ER calcium homeostasis), CAPZA2 and TWF1 (actin capping/dynamics for vesicle movement), SH3GLB1/endophilin B1 (autophagy initiation, membrane curvature), PERP (p53 target, tight junction/apoptosis), KRAS (oncogenic GTPase, vesicle trafficking). Together these define an ER stress and vesicular trafficking response activated in inflamed colonocytes, consistent with the ER stress known to occur in UC epithelium.
Genes
Most correlated modules
- Arp2/3 Actin Branching · correlation 0.85
- Integrin Adhesion Signaling · correlation 0.84
- mTOR Lysosomal Sensing · correlation 0.83
- Inflammatory Cytoskeletal Remodeling · correlation 0.83
- Hypoxic Oxidative Stress · correlation 0.82
- Lysosomal Autophagy Trafficking · correlation 0.81
- Ubiquitin Signaling Response · correlation 0.79
- Actin-Motor Organization · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.