Inflammatory Cytoskeletal Remodeling
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 26 genes have a known function matching the annotation |
Why this annotation
This module shows the strongest inflammation signal in the batch (delta_inflammation = 0.940, delta_inflammation_UC = 1.044, both sig.) and is enriched in inf_colono. Hub genes CLIP1 (CLIP-170, microtubule plus-end tracking), KIF2A (kinesin-13, microtubule depolymerization), MYO6 (myosin VI, endocytic trafficking), CORO1C (coronin, actin dynamics), ARHGEF12 (LARG, RhoA GEF), SLK (Ste20-like kinase, cytoskeletal regulation), CTTNBP2NL (cortactin-binding, actin), and FGD4 (FYVE-domain RhoGEF) define a cytoskeletal remodeling program. ITPR3 (IP3R3, calcium release), EHD1 (endosomal recycling), BIRC6 (anti-apoptotic E3 ligase), SP1 (master transcription factor), and RALGPS2 (RalGPS2, Ral GEF) add calcium signaling and endosomal components. This program likely reflects cytoskeletal and endosomal remodeling in colonocytes responding to inflammatory signals, a neighbor to M74 which also captures cytoskeletal programs.
Genes
Most correlated modules
- Senescent Colonocyte Transcription · correlation 0.85
- Cellular Senescence · correlation 0.83
- ER Stress & Trafficking · correlation 0.83
- Colonocyte Senescence · correlation 0.78
- Ubiquitin-Proteasome System · correlation 0.78
- Actin-Motor Organization · correlation 0.74
- AP-1 Stress Survival · correlation 0.69
- Vesicular Trafficking · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.