Colonocyte Senescence
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include CDKN2B (p15, canonical senescence marker), SGK1 (stress kinase enriched 4.1x in sen_colono), PNPLA2, AHNAK, and PLEC, all enriched in sen_colono subset. PKP3 and CTNND1 reflect desmosomal/adherens junction remodeling typical of senescent epithelial cells. LLGL2 and CSNK1D relate to polarity loss. Strong delta_inflammation signal (0.791) consistent with senescence-associated secretory phenotype context. Multiple genes show sen_colono enrichment, and CDKN2B is a direct CDKN2 family senescence effector.
Genes
Most correlated modules
- Membrane Cytoskeletal Remodeling · correlation 0.82
- Colonocyte Cytoskeletal Contractility · correlation 0.82
- Senescent Colonocyte Transcription · correlation 0.79
- Inflammatory Cytoskeletal Remodeling · correlation 0.78
- AP-1 Stress Survival · correlation 0.76
- Actin-Motor Organization · correlation 0.74
- Transcriptional Golgi Remodeling · correlation 0.73
- Lipid Metabolism · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.