Inflammasome Pyroptosis
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include HK2 (hexokinase 2, key glycolytic enzyme upregulated in Warburg metabolism), GSDMD (gasdermin D, executor of pyroptosis), UNC13D (Munc13-4, required for inflammasome-dependent secretion and cytotoxic granule release), TCIRG1 (vacuolar ATPase subunit, lysosomal acidification), TAPBP (tapasin, MHC-I antigen loading), ASS1 (argininosuccinate synthase, arginine/NO metabolism), SLC40A1 (ferroportin, iron export), CARD10 (NF-κB signaling), GBP3 (ISG), and HLA-E. The combination of GSDMD + UNC13D + CARD10 strongly indicates an inflammasome/pyroptosis program. HK2 metabolic reprogramming co-occurs. Strongly upregulated in both UC and CD inflammation.
Genes
Most correlated modules
- IFN-γ Antiviral Response · correlation 0.93
- IFN-γ Metabolic Reprogramming · correlation 0.89
- TNF Apoptosis Resistance · correlation 0.89
- Senescent Cell Death · correlation 0.89
- TGF-β Chromatin Regulation · correlation 0.88
- Inflamed Barrier Remodeling · correlation 0.88
- Basement Membrane Remodeling · correlation 0.85
- Type I Interferon Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.