Proteasome Assembly
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include RTRAF (RNA transcription, translation and transport factor), PSMA7, PSMB6, PSMA4, POMP (proteasome subunits and assembly chaperone), SF3B6, SNRPD3, TXNL4A (spliceosome components), SUB1 (transcriptional coactivator), SERP1 (stress-associated ER protein, ERAD), SEC61B (ER translocon), ERP29 (ER protein), ATP6V1G1 (vacuolar H+-ATPase), NDUFB8 (Complex I), HSD17B10 (mitochondrial), PDCD6, JTB, DYNLL1, RAB25, BRI3. Proteasome subunits (PSMA7, PSMB6, PSMA4, POMP) are the most prominent functional cluster. ER components (SERP1, SEC61B, ERP29) form a secondary cluster. The module is a mixed housekeeping module; proteasome assembly is the strongest identifiable program. Neighbor M115 also has proteasome genes, consistent with shared proteasome co-expression in this neighborhood.
Genes
Most correlated modules
- Proteasome Activity · correlation 0.94
- ER Protein Processing · correlation 0.91
- Complex IV Assembly · correlation 0.90
- ER Stress & UPR · correlation 0.90
- RNA Processing Translation · correlation 0.89
- Oxidative Phosphorylation · correlation 0.88
- Oxidative Phosphorylation · correlation 0.85
- Mitochondrial Ribosome · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.