Cell Cycle Machinery
Gene co-expression module in Colonocytes
| Category | Cell cycle |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
Top hub ANAPC11 is a core APC/C ubiquitin ligase subunit central to cell cycle progression. Supporting genes include RAN (mitotic nuclear transport), MZT2A/MZT2B (gamma-TuRC microtubule nucleation), CCT7 (chaperonin for cytoskeletal folding), CDC123 (eIF2 assembly/cell cycle), and SNRPB/LSM3 (RNA processing). The module is enriched in crypt_colono (proliferating crypt cells) and decreases with inflammation, consistent with a proliferative crypt cell program. ANAPC11 as the dominant hub with MZT2A/B and RAN points to cell cycle machinery as the defining program.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.99
- CCT Chaperonin Folding · correlation 0.98
- snRNP Splicing · correlation 0.97
- Mitochondrial Ribosome · correlation 0.96
- eIF3 Translation Initiation · correlation 0.96
- Protein Homeostasis Housekeeping · correlation 0.95
- Ribosome Biogenesis · correlation 0.95
- SUMOylation Chromatin · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.