Mitochondrial Ribosome
Gene co-expression module in Colonocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Five of eight genes are mitoribosome subunits: MRPL54, MRPL52, MRPL57 (large subunit), MRPS15, MRPS16 (small subunit). C19orf53 is a mitochondrial protein. TRAPPC2L is a TRAPP complex subunit involved in vesicle trafficking. GSTO1 is glutathione S-transferase omega-1 with mitochondrial localization and roles in oxidative stress. The module is uniformly expressed, core coherence, and shows significant decrease in CD inflammation. In the context of the OxPhos/mitochondrial neighborhood, this module represents mitochondrial ribosome function, required for translation of mtDNA-encoded OxPhos subunits.
Genes
Most correlated modules
- RNA Processing Translation · correlation 0.97
- Cell Cycle Machinery · correlation 0.96
- CCT Chaperonin Folding · correlation 0.96
- Mitochondrial Translation · correlation 0.94
- snRNP Splicing · correlation 0.94
- Oxidative Phosphorylation · correlation 0.94
- Protein Homeostasis Housekeeping · correlation 0.94
- eIF3 Translation Initiation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.