Proteasome Activity
Gene co-expression module in Colonocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 41 genes have a known function matching the annotation |
Why this annotation
Top hub genes include OST4 (oligosaccharyltransferase complex, ER N-glycosylation), LAMTOR5 (Ragulator complex, lysosomal mTOR signaling), SEM1 (proteasome regulatory particle), NOP10 (H/ACA snoRNP, ribosome biogenesis), SPCS1 (signal peptidase complex, ER), SRSF9 (serine/arginine splicing factor), BRK1/ARPC5L (Arp2/3 actin branching complex), MRPL33 (mitoribosome), NDUFV2 (Complex I), HSBP1 (heat shock factor binding), TRAPPC1 (TRAPP vesicle tethering), CLTA (clathrin light chain), PSMB5/PSMB1/PSMB3 (proteasome beta subunits), COPS9 (COP9 signalosome, proteasome regulation), TBCA (tubulin-specific chaperone), MGST2 (glutathione transferase), SRP14 (signal recognition particle). The proteasome subunits (PSMB5, PSMB1, PSMB3, SEM1, COPS9) are the most coherent functional cluster among the top-ranked genes. This module is a mixed housekeeping module but proteasome function is the dominant identifiable program among hub genes.
Genes
Most correlated modules
- ER Protein Processing · correlation 0.96
- Complex IV Assembly · correlation 0.95
- Proteasome Assembly · correlation 0.94
- RNA Processing Translation · correlation 0.93
- Oxidative Phosphorylation · correlation 0.93
- Protein Homeostasis Housekeeping · correlation 0.92
- Oxidative Phosphorylation · correlation 0.91
- Cell Cycle Machinery · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.