RNA Processing Translation
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 15 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include ERH (enhancer of rudimentary homolog, involved in pyrimidine metabolism and RNA processing), COX7A2L (mitochondrial supercomplex assembly factor), THOC7 (THO complex, mRNA export), SSBP1 (mitochondrial ssDNA binding protein), PARK7 (DJ-1, mitochondrial quality control), MRPL51 (mitoribosome large subunit), EIF3M/H/I (eukaryotic translation initiation factor 3 subunits), GTF3A (RNA Pol III transcription factor), SNRPG (spliceosome Sm protein), LSM5 (RNA processing/splicing), REXO2 (RNA exonuclease), POLR2K (RNA Pol II subunit), METTL5 (18S rRNA m6A methyltransferase), PDCD2 (RNA granule component), AIMP1 (aminoacyl-tRNA synthetase complex). The module is enriched in crypt colonocytes and shows the same CD-inflammation-loss pattern as neighbors. The dominant theme is RNA processing and translation, with secondary mitochondrial components. The co-expression with OxPhos neighbors likely reflects shared crypt colonocyte identity.
Genes
Most correlated modules
- Cell Cycle Machinery · correlation 0.99
- CCT Chaperonin Folding · correlation 0.97
- Mitochondrial Ribosome · correlation 0.97
- snRNP Splicing · correlation 0.96
- Protein Homeostasis Housekeeping · correlation 0.96
- eIF3 Translation Initiation · correlation 0.96
- Oxidative Phosphorylation · correlation 0.95
- Ribosome Biogenesis · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.