Colonocyte Detoxification
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 30 genes have a known function matching the annotation |
Why this annotation
Hub genes include CDH17 (colonocyte-specific cadherin), SULT1B1 and PAPSS2 (sulfation pathway enzymes), NQO1 and AKR1B10 (phase II detoxification enzymes), ATP6V0D1 and SPPL2A (lysosomal/vacuolar processing), and SORT1 (lysosomal sorting receptor). Together these define a mature colonocyte xenobiotic detoxification and sulfation program. Upregulation in UC inflammation (delta_inflammation_UC=0.644 sig.) is consistent with colonocyte stress-adaptive detox response. Strong coherence and uniform expression support a bona fide colonocyte identity program.
Genes
Most correlated modules
- Lysosomal Lipid Stress · correlation 0.94
- PPARG Lipid Metabolism · correlation 0.88
- Lipid Metabolism · correlation 0.87
- Mature Colonocyte Identity · correlation 0.87
- Colonocyte Cytoskeletal Contractility · correlation 0.86
- ESCRT Membrane Remodeling · correlation 0.85
- Endosomal Vesicle Trafficking · correlation 0.85
- Epithelial Junction Integrity · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.