Membrane Repair Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub gene PARM1 (prostate androgen-regulated mucin-like protein 1) is strongly upregulated in inflamed epithelium and is a known inflammation-responsive gene in colon. MYOF (myoferlin) mediates membrane fusion and repair, upregulated in inflammatory contexts. ACVRL1 (ALK1) is a TGF-β/BMP type I receptor involved in epithelial remodeling. SPTBN1 (spectrin βII) is a cytoskeletal scaffold. COPG1 and SEC24A are COPI/COPII vesicle coat proteins (linking to M13 neighborhood). ATP11B is a P4-ATPase lipid flippase. CTSS (cathepsin S) is a lysosomal cysteine protease upregulated in inflammation. SLC44A4 is a choline transporter. The module shows strong UC-specific inflammation (delta_UC=1.206, sig.) and significant reversal with UC remission (delta_remission_UC=-0.871, sig.), the strongest remission signal in the batch. PARM1+MYOF+ACVRL1 together suggest a membrane repair and TGF-β/BMP remodeling response specific to UC-inflamed colonocytes.
Genes
Most correlated modules
- Lysosomal Lipid Stress · correlation 0.89
- Inflammasome Activation · correlation 0.88
- Integrin Adhesion Signaling · correlation 0.88
- Epithelial Junction Integrity · correlation 0.87
- Inflamed Barrier Remodeling · correlation 0.86
- Arp2/3 Actin Branching · correlation 0.83
- Inflammasome Pyroptosis · correlation 0.82
- TGF-β Chromatin Regulation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.