Arp2/3 Actin Branching
Gene co-expression module in Colonocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 39 genes have a known function matching the annotation |
Why this annotation
Hub genes CAPZB, ARPC5, ARPC2, ARPC4 encode Arp2/3 complex subunits responsible for actin filament branching. RAC1 is the canonical upstream activator of Arp2/3. CAPZA1 is another barbed-end capping protein. RAB11A and RAB18 link actin dynamics to vesicle recycling. GNB1 provides upstream G-protein input. ACTR3 (Arp3) is a direct Arp2/3 component. The module is strongly upregulated in UC inflammation. Neighbor M69 shares CFL1/DIAPH1/PAK2 actin regulators, and M13 shares ARPC1A/ARPC3, confirming a neighborhood-wide actin remodeling theme. This module specifically captures the Arp2/3-RAC1 branched actin polymerization axis.
Genes
Most correlated modules
- Integrin Adhesion Signaling · correlation 0.96
- Hypoxic Oxidative Stress · correlation 0.94
- Ubiquitin Signaling Response · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.92
- mTOR Lysosomal Sensing · correlation 0.91
- Lysosomal Autophagy Trafficking · correlation 0.90
- Epithelial Junction Integrity · correlation 0.90
- ER-Golgi Trafficking · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.