MHC antigen presentation
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 16 genes have a known function matching the annotation |
Why this annotation
The module is dominated by MHC class I (HLA-A/B/C/F, B2M) and class II genes (CD74, HLA-DR/DP/DQ/DM), plus the IFN-induced genes IFI27, PLAAT4 and GSDMB. Expression is uniform, pointing to IFN-gamma-induced epithelial antigen presentation rather than immune contamination. It is downstream of the STAT1 program in M32.
Genes
B2M, CD74, GSDMB, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-F, IFI27, PLAAT4
Most correlated modules
- IFN-gamma response · correlation 0.74
- IFN-gamma STAT1 signaling · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.