Core energy metabolism
Gene co-expression module in Enterocytes
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
This is a mixed module of highly expressed metabolic housekeeping genes. It contains the glycolytic enzyme GAPDH, the fatty-acid beta-oxidation enzyme ACAA2, the malic enzyme ME2, the electron carrier CYCS, the antioxidant SOD1 and the pyrophosphatase PPA1. Additional members are PSME2 (immunoproteasome), CFL1 and P4HB. Expression is uniform across subsets. It neighbors the M16 translation/OxPhos housekeeping module, suggesting a general metabolic-activity axis in enterocytes. The label is therefore broad core energy metabolism.
Genes
ACAA2, CFL1, CYCS, GAPDH, ME2, P4HB, PPA1, PSME2, SOD1
Most correlated modules
- Actin cytoskeleton · correlation 0.81
- Oxidative Phosphorylation · correlation 0.74
- ER chaperone/UPR · correlation 0.72
- Respiratory Chain Subunits · correlation 0.71
- Mitochondrial Energy Metabolism · correlation 0.70
- Respiratory Chain OXPHOS · correlation 0.70
- Electron Transport Chain · correlation 0.69
- ATP Synthase OXPHOS · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.