IFN-gamma response
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PARP14, GBP1/2, TAPBP, IRF1, PARP9, APOL6, TYMP and NUB1 form a canonical IFN-gamma/IRF1-driven program in colonocytes, typical of inflamed colon. It includes antigen presentation (TAPBP) and GBP-mediated cell-autonomous immunity. BIRC3 and RNF213 are also IFN-inducible. The module is tight (core coherence) and anchors the batch's inflammatory neighborhood.
Genes
APOL6, BIRC3, GBP1, GBP2, IRF1, NUB1, PARP14, PARP9, RNF213, TAPBP, TYMP
Most correlated modules
- IFN-gamma STAT1 signaling · correlation 0.89
- STAT3/JNK signaling · correlation 0.85
- Inflammatory cell death · correlation 0.85
- Inflammatory hypoxic response · correlation 0.84
- Colonocyte terminal differentiation · correlation 0.82
- NF-kB epithelial activation · correlation 0.82
- Long-gene nuclear transcripts · correlation 0.81
- Basal adhesion remodeling · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.