B2M — Beta-2-microglobulin

B2M belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

B2M's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	MHC-I Antigen Presentation Anti-viral	BANK1, CD48, CYSLTR1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F +1 more	View in SCUBA
CD4⁺ T cells	Inflammatory activation Immune regulation	ACP5, CALCOCO1, CCNG2, CHST11, CORO1A, HLA-A, IL32, PITPNM2 +10 more	View in SCUBA
CD8⁺ T cells	Cytotoxic Effector cytotoxicity	APOBEC3H, CCL4, CCL5, CD52, CYBA, GZMH, HCST, HLA-A +4 more	View in SCUBA
Endothelial	MHC Class I Presentation Inflammation	BST2, BTN3A1, BTN3A2, CYSTM1, HLA-A, HLA-B, HLA-C, HLA-F +1 more	View in SCUBA
Enterocytes	MHC antigen presentation Inflammation	CD74, GSDMB, HLA-A, HLA-B, HLA-C, HLA-DMB, HLA-DPA1, HLA-DPB1 +7 more	View in SCUBA
Fibroblasts	Immunoproteasome MHC-I Inflammatory	BST2, EPSTI1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27, PPA1 +7 more	View in SCUBA
Gamma-delta T cells	Effector IFN Response cytotoxicity	AGTRAP, ANXA1, CYBA, EMP3, FXYD5, GZMM, IFITM1, IFITM2 +9 more
Glial cells	MHC-I Antigen Presentation Inflammation	BTN3A2, C1R, C1S, CST3, HLA-A, HLA-B, HLA-C, IFI27 +4 more	View in SCUBA
Goblet cells	MHC Class I Antigen Presentation Immune function	APOL1, APOL6, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IFI27 +4 more	View in SCUBA
Hematopoietic progenitor cells	MHC-I Antigen Presentation Myeloid development	ACTB, CALM2, CAPG, CYBA, EVI2A, EVI2B, FUT7, HLA-A +10 more
Innate lymphoid cells	NK Receptor Signaling Cytotoxicity	CD48, CLEC2B, DCK, FCER1G, FKBP11, GPR108, HLA-A, HLA-B +12 more	View in SCUBA
Macrophages	MHC-II Antigen Presentation Innate immunity	AIF1, C1QA, C1QB, C1QC, CD68, CD74, CST3, CTSC +19 more	View in SCUBA
Mucosal-associated invariant T cell	Cyclophilin-Mediated Folding Housekeeping	BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH, GTF3A +10 more
Natural Killer cells	NK Cytotoxic Signaling Cytotoxicity	APOBEC3G, CALM1, CD48, GLIPR2, HCST, MYL12A, TMSB10, TRGC1 +1 more	View in SCUBA
Neutrophils	Neutrophil Survival Program Inflammatory	BCL2A1, CEBPB, EIF1, FTH1, FTL, H3-3A, H3-3B, PNRC1 +2 more
Smooth muscle cells	MHC-I antigen presentation Inflammation	HLA-A, HLA-B, HLA-C, IFI27, NDUFA4, S100A4, S100A6, TMSB4X +2 more	View in SCUBA

About the gene

Chromosome	15: 44711358-44718851
Predicted location	Secreted
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters
Biological process	Immunity

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.