TMED4 — Transmembrane p24 trafficking protein 4
TMED4 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMED4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Enterocyte lipid metabolism Lipid metabolism | CYP4F2, DHDH, GPX4, MS4A10, OCIAD2, PCK1, PHYH, PLIN2 +3 more | View in SCUBA |
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | ATXN2, CARMIL2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2 +8 more | |
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more | View in SCUBA |
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more | View in SCUBA |
About the gene
| Synonyms | HNLF, p24a3, p24alpha3 |
|---|---|
| Chromosome | 7: 44577894-44582287 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Protein transport, Transport |
Function
Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.