TCR Signal Regulation
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 31 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 31 genes have a known function matching the annotation |
Why this annotation
Hub genes TRAT1 (TRIM), UBASH3A, DGKA, CAMK4, GNAQ, and TRAF5 are all classical TCR signaling regulators. TRAT1 (also known as TRIM) is a direct TCR co-signaling adapter; UBASH3A is a ubiquitin-associated phosphatase that dampens TCR signaling; DGKA encodes diacylglycerol kinase alpha, a key negative regulator of DAG-mediated TCR signaling; CAMK4 mediates calcium-dependent TCR downstream signaling; GNAQ encodes Gαq involved in PLC activation. IL7R and CCR5 indicate a naïve/resting T cell context. PATJ, CASK are scaffold proteins involved in cell polarity and signaling complex assembly. RASGRF2 is a Ras guanine nucleotide exchange factor linked to T cell development. TRAF5 modulates NF-κB signaling downstream of costimulation. CD84 is a T cell costimulatory molecule. The module as a whole reflects TCR signal attenuation and regulation in resting gd T cells.
Genes
ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6, DGKA, EEIG1, GNAQ, HELB, IL7R, JAML, MX1, PATJ, R3HDM4, RASGRF2, RCAN3, RETREG1, SLC7A6, STAMBPL1, STAT5A, STX17, SUPT3H, TMEM123, TRAF5, TRAT1, UBASH3A, WDR86, ZEB1
Most correlated modules
- PI3K-AKT Regulation · correlation 0.69
- Redox Stress Response · correlation 0.57
- PLZF Innate-like Effector · correlation 0.53
- Naïve T Cell State · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.