Redox Stress Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes BEX2 and BEX4 (Brain Expressed X-linked) are expressed in T cells and have been linked to cell survival, apoptosis regulation, and neurotrophin signaling. CITED4 is a transcriptional coactivator. SELENOM is a selenoprotein with antioxidant function in the ER. PLXDC1 is a receptor involved in cell survival and angiogenesis. MICAL1 mediates actin depolymerization and redox signaling. LTBP3 is involved in TGF-beta latency and activation. FTL (ferritin light chain) reflects iron storage/oxidative stress. SNRPN is involved in RNA splicing and imprinting. The moderate coherence and mixed membership scores (many 'weak') indicate this is a loosely defined module. The BEX family members, SELENOM, and FTL together suggest a stress-response/redox program, possibly linked to ER redox or survival signaling in a subset of gd T cells. However, the module is not tightly defined.
Genes
BEX2, BEX4, CITED4, EEF1A1, FMNL3, FTL, GRINA, LTBP3, MICAL1, PLXDC1, RIC3, SELENOM, SNRPN, UBE2W
Most correlated modules
- PI3K-AKT Regulation · correlation 0.64
- TCR Signal Regulation · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.