SINHCAF — SIN3-HDAC complex associated factor
SINHCAF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SINHCAF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, AGFG1, CCND3, CD164, CHMP2B, DBF4, GHITM, HNRNPL +9 more | View in SCUBA |
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD +7 more | View in SCUBA |
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | ATXN2, CARMIL2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2 +8 more |
About the gene
| Synonyms | C12orf14, FAM60A, TERA |
|---|---|
| Chromosome | 12: 31280584-31327058 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway. Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.