USP25 — Ubiquitin specific peptidase 25
USP25 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
USP25's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, HSPA2, ISG20L2, MAP3K13, MLF1, MORN3 +7 more | View in SCUBA |
| Gamma-delta T cells | PI3K-AKT Regulation TCR Signaling | ATXN2, CARMIL2, ERO1A, GRAMD1A, KMT2A, LARP4B, NIN, PCNX2 +8 more | |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4 +25 more | View in SCUBA |
About the gene
| Synonyms | USP21 |
|---|---|
| Chromosome | 21: 15729982-15880064 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
| Biological process | Ubl conjugation pathway |
Function
Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response. Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2. Regulates KEAP1- NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti- oxidation gene expression program. Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2. In turn, restricts virus production by regulating cholesterol biosynthetic flux. Acts as a negative regulator of interleukin-17- mediated signaling and inflammation through the removal of 'Lys-63'- linked ubiquitination of TRAF5 and TRAF6. Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.