DNA Replication Licensing
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 11 genes have a known function matching the annotation |
Why this annotation
Nearly all hub genes are MCM helicase complex subunits (MCM2, MCM3, MCM4, MCM5, MCM7), which are the central licensing factors for DNA replication initiation at origins in S phase. Supporting genes include HELLS (LSH helicase, chromatin remodeling at replication forks), BRCA1 (replication-coupled DNA repair), TIMELESS (replication fork protection/checkpoint), RFC4 (replication factor C clamp loader), CHAF1A (CAF-1 histone chaperone, deposits H3/H4 behind the fork), PAQR4 (progesterone receptor, may regulate S-phase entry). The module is core-coherent with very low mean expression (0.065) and 5.6% positive cells, consistent with a rare cycling population. This is a tight DNA replication initiation module. Neighbor context supports this as S-phase licensing within the cell cycle neighborhood.
Genes
BRCA1, CHAF1A, HELLS, MCM2, MCM3, MCM4, MCM5, MCM7, PAQR4, RFC4, TIMELESS
Most correlated modules
- S-phase Replication · correlation 0.95
- Cell Cycle Entry · correlation 0.86
- Mitotic Spindle · correlation 0.85
- Cellular Homeostasis · correlation 0.84
- Mitosis Execution · correlation 0.81
- Basal Lipid Metabolism · correlation 0.79
- G1/S Entry · correlation 0.76
- Mitochondrial OxPhos · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.