Mitotic Spindle
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 18 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes TUBB (beta-tubulin), CKAP5 (ch-TOG, microtubule polymerase), CNTRL (centriolin/centrosome), SMC1A/SMC3 (cohesin complex), NCAPD2 (condensin complex), TMPO (thymopoietin/nuclear lamina disassembly in mitosis), SSRP1/SUPT16H (FACT complex/chromatin remodeling during replication), SKA2 (spindle and kinetochore-associated), HIRIP3 (histone regulator), DNMT1 (DNA methylation maintenance during replication), NUP50 (nucleoporin), FAM111A (DNA replication licensing), RFC2 (replication factor C), RNASEH2A (Okazaki fragment processing), GMPS (GMP synthetase/nucleotide synthesis), CAPRIN1 (cell cycle-associated), DEK (chromatin organizer, S phase), CDK5RAP2 (centrosome/mitosis). This is a coherent G2/M and S-phase transition module focused on spindle assembly, chromosome condensation, and chromatin remodeling during mitosis. Neighboring modules M83 (S-phase/replication), M88 (M-phase/mitosis), and M183 (MCM helicase) confirm a cell cycle neighborhood.
Genes
CAPRIN1, CDK5RAP2, CKAP5, CNTRL, DEK, DNMT1, FAM111A, GMPS, HADH, HIRIP3, NCAPD2, NUP50, RNASEH2A, SKA2, SMC1A, SMC3, SSRP1, SUPT16H, TMPO, TUBB
Most correlated modules
- S-phase Replication · correlation 0.89
- Mitosis Execution · correlation 0.88
- mRNA Splicing · correlation 0.85
- DNA Replication Licensing · correlation 0.85
- Interferon Stimulated Response · correlation 0.83
- Replication-Coupled Histones · correlation 0.81
- Cellular Homeostasis · correlation 0.80
- DNA Damage Repair · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.