S-phase Replication
Gene co-expression module in Gamma-delta T cells
| Category | Cell cycle |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 17 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes are tightly focused on S-phase DNA synthesis and replication: TYMS (thymidylate synthase, dTTP biosynthesis), TK1 (thymidine kinase, nucleotide salvage), DHFR (dihydrofolate reductase, dTMP synthesis), RRM1 (ribonucleotide reductase M1, dNTP synthesis), PCNA (sliding clamp for DNA polymerase delta), FEN1 (flap endonuclease, Okazaki fragment maturation), PCLAF (PCNA-associated factor), CDT1 (replication licensing, works with MCM), CLSPN (replication checkpoint mediator/Claspin), ATAD5 (PCNA unloading after replication), BRCA2 (replication fork protection/HR), FANCI (Fanconi anemia pathway/replication stress), CENPU/CENPH/CENPM (centromere proteins, kinetochore assembly), SMC2 (condensin), TCF19 (transcription in S phase), DYNC2I2 (dynein), NRM (nuclear envelope). This module is the canonical S-phase/nucleotide-synthesis and replication execution module, complementing M183 (licensing) and M88 (mitosis). Core coherence throughout.
Genes
ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN, DHFR, DYNC2I2, FANCI, FEN1, NRM, PCLAF, PCNA, PHF19, RRM1, SMC2, SNRNP25, TCF19, TK1, TYMS
Most correlated modules
- DNA Replication Licensing · correlation 0.95
- Mitosis Execution · correlation 0.95
- Mitotic Spindle · correlation 0.89
- Replication-Coupled Histones · correlation 0.85
- Cellular Homeostasis · correlation 0.84
- G1/S Entry · correlation 0.84
- Basal Lipid Metabolism · correlation 0.76
- Cell Cycle Entry · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.