Autophagy & Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
ATG7 (autophagy E1-like activating enzyme) and TBC1D5 (Rab7 GAP, autophagosome-lysosome fusion regulator) are core autophagy genes. VPS13B encodes a lipid transfer protein at ER-endosome contacts critical for vesicular trafficking. ABCD2 (peroxisomal VLCFA transporter) and SLFN12L (Schlafen antiviral/immune regulatory) add a metabolic-immune dimension. IKBKE (IKKε) links to innate immune/antiviral signaling. ZBTB20 and KLF12 are transcription factors associated with lymphocyte differentiation. TMEM131L modulates TGF-β signaling. SPIDR and ASCC3 participate in DNA repair. The most coherent unifying program is autophagy and intracellular lipid/membrane trafficking, consistent with a homeostatic recycling state in gd T cells. Neighbor context (M46 mTOR signaling) supports a metabolic-regulatory neighborhood.
Genes
ABCD2, ASCC3, ATG7, ATP9B, BTBD9, IKBKE, ITFG1, KLF12, PALM2AKAP2, PIBF1, SCLT1, SLFN12L, SPIDR, TBC1D5, TMEM131L, TMLHE, USP15, VPS13B, ZBTB20, ZMYM4
Most correlated modules
- mTOR-Exocyst Signaling · correlation 0.78
- JNK/MAPK Stress Signaling · correlation 0.52
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.