ASCC3 — Activating signal cointegrator 1 complex subunit 3
ASCC3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ASCC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD4 Lineage Identity T cell development | ACAA1, AGPAT3, ATF2, KIFAP3, KXD1, NEK7, PARP4, PPM1A +6 more | View in SCUBA |
| Enterocytes | Long-gene intronic signal Technical artifact | CASK, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A, RALGAPA2 +5 more | View in SCUBA |
| Gamma-delta T cells | Autophagy & Trafficking Housekeeping | ABCD2, ATG7, ATP9B, BTBD9, IKBKE, ITFG1, KLF12, PALM2AKAP2 +11 more | |
| Mucosal-associated invariant T cell | RAS-GEF Signaling TCR Signaling | FBXW7, GPATCH8, HERC1, RASGRF2, RASGRP1, TLK1, TNRC6B, TRAPPC9 +2 more |
About the gene
| Synonyms | ASC1p200, dJ121G13.4, dJ467N11.1, HELIC1, RNAH |
|---|---|
| Chromosome | 6: 100508194-100881372 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, Isomerase |
| Biological process | DNA damage, DNA repair |
Function
ATPase involved both in DNA repair and rescue of stalled ribosomes. 3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single- stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.