TMEM131L — Transmembrane 131 like
TMEM131L belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM131L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BACH2, BCL6, BPTF, GGA2, MAP4K4, MBD4, MCTP2, MSI2 +7 more | View in SCUBA |
| Gamma-delta T cells | Autophagy & Trafficking Housekeeping | ABCD2, ASCC3, ATG7, ATP9B, BTBD9, IKBKE, ITFG1, KLF12 +11 more | |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANK3, ARHGAP15, ARL15, BCAS3, CAMKMT, CCDC91, DPYD, EDA +13 more | |
| Smooth muscle cells | HOX Positional Identity Development | AC027644.3, AC092164.1, AL139246.5, FAM122A, FAM241A, GRAMD2B, HOXB-AS1, HOXB-AS3 +10 more | View in SCUBA |
About the gene
| Synonyms | DKFZp586H1322, KIAA0922 |
|---|---|
| Chromosome | 4: 153466346-153636711 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Wnt signaling pathway |
Function
Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.