SCUBA

ZBTB20 — Zinc finger and BTB domain containing 20

ZBTB20 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ZBTB20's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsB-cell Maturation
B cell maturation
ANK3, ANTXR2, CD24, COL4A3, COL4A4, CSGALNACT1, ITM2C, PDCD4 +3 moreView in SCUBA
CD4⁺ T cellsChromatin transcription regulation
DNA/chromatin regulation
ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3 +10 moreView in SCUBA
EnterocytesEnterocyte identity TFs
Epithelial development
CAMK2G, MALRD1, MAML3, PBX1, PLXDC2, SPTLC3, TPD52, TTC17View in SCUBA
FibroblastsTGF-beta Response
ECM remodeling
C1orf21, CBR3, CNRIP1, DOK5, FREM1, GUSB, HTRA1, LRRN4CL +7 moreView in SCUBA
Gamma-delta T cellsAutophagy & Trafficking
Housekeeping
ABCD2, ASCC3, ATG7, ATP9B, BTBD9, IKBKE, ITFG1, KLF12 +11 more
Glial cellsGlial Homeostatic Identity
Development
GAS7, NUCKS1, QKI, SEMA3C, SIPA1L2, SORCS1, TMEM245, VCLView in SCUBA
Goblet cellsmRNA Stability Control
RNA processing & translation
BTG1, DNAJB6, PNRC1, SRSF5, TENT5C, TSC22D1, TUBA1A, TXNIP +5 moreView in SCUBA
Hematopoietic progenitor cellsErythroid Maturation Signaling
Erythropoietic
ATP1B1, ELMO1, GUCY1B1, HTR1F, IGSF10, MED12L, PLXDC2, PRKACB +3 more
Innate lymphoid cellsPyruvate Metabolism
Metabolism
ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 moreView in SCUBA
MacrophagesGolgi Vesicle Trafficking
Vesicular traficking
ARMH3, ATG7, CCDC91, CDK17, CLASP1, COG5, COMMD10, COP1 +24 moreView in SCUBA
Mucosal-associated invariant T cellCalcium Signal Integration
TCR Signaling
ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more
Natural Killer cellsILC1/NK Cytotoxic
Cytotoxicity
A1BG, CASK, CLDND1, EIF3G, GZMK, ITM2C, KLRB1, NCF1 +4 moreView in SCUBA
NeutrophilsNeutrophil Differentiation
Developmental
DACH1, DGKD, FAR1, MPP7, MSRA, PAM, PLCL2, PTBP2 +1 more
PericytesPericyte Vascular Identity
Developmental
AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C +10 moreView in SCUBA
Smooth muscle cellsSTAT3 transcriptional program
Activation
DDX3X, FAM210B, HLA-E, HNRNPH1, ID4, ITPR1, NOLC1, RAB21 +2 moreView in SCUBA

About the gene

SynonymsDKFZp566F123, DPZF, ODA-8S, ZNF288
Chromosome3: 114314500-115147292
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Function

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.